| SpCrossreactivity | The mouse SG11-P peptide sequence is 100% conserved in rabbit, ovine, and sheep, 94% in equine and rat, 89% in pig, 84% in human, 86% in chicken SGLT-1 (1). SG11-P sequence also has high sequence homology with the low affinity SGLT-3 in mouse SGLT-4a/4b (84%), human SAAT1/SGLT-3 (78%), and SGLT-2 from human and rat (63%). SG11-P may also be conserved in other related trasnproters. Antibodies generated using this sequence have been shown to recognize specific SGLT-1 protein of 70-77 kDa in a variety of species (rabbit, rat, mouse, human, pig, cat, dog; reptiles and birds) by Western blotting (2). It is not known if anti-SG11 will also identify SGLT-1 like or SGLT-2 or SGLT-3 proteins. Therefore, this antibody may be suited to detect cells or tissues that contains only a given SGLT or to detct recombinant purified SGLT1-3 |