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Home Page >Online Product Catalog > Primary Antibodies > Beta-Site APP-Cleaving Enzymes (BACE/Asp2/Asp1) > Alpha-Secretase peptide substrate Human APP605-619, >95% pure (Peptide)

Alpha-Secretase peptide substrate Human APP605-619, >95% pure

Catalog# Product Description Product Type Antibody Type Size Price
TACE-SW-20 Alpha-Secretase peptide substrate Human APP605-619, >95% pure Peptide 20 mg $1,550.00


Pure Peptide

A fluorescence energy transfer (FRET) peptide substrate for tumor necrosis factor (TNF) -¿¿convertase (TACE) (Km ~ 19 ¿M). Cleavage of this TACE substrate II occurs between the alanine and valine residues. Useful for the screening of TACE inhibitors

Recommended usage: 50 mM Tricine buffer, pH 7.5, containing 100 mM NaCl, 10 mM CaCl2, and 1 mMZnCl2, 10 ¿M TACE Substrate II, 600 nM TACE; incubate at 27°C with mechanical shaking; reaction can be quenched with 50 mM EDTA (final concentration) ; cleavage monitored by excitation at ~ 320 nm and emission at ~ 395 nm

For research use only, not for diagnostic or therapeutic use.

Data Sheets


General Information

Recently TACE, a member of the ADAM family (A Disintegrin And Metalloprotease family) protease has been shown to play a central role in a regulated cleavage of human APP. Inhibition of TACE affects both APP secretion and A¿ formation in cultured cells (1

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