Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization.
10-aa peptide of mouse BACE/Asp2 ; Designated (BACE12-P or control peptide) conjugated to KLH; epitope location ~ N-terminus, Extracellular domain
The mouse BACE12-P sequence is 100% conserved in human and 90% in rat BACE/Asp2. No significant sequence homology exists with BACE2/Aps1, a homolog of BACE, or other Asps. Antibody crossreactivity in various species is not established.
For research use only, not for diagnostic or
¿-amyloid (A¿) deposition in the brain is the hallmark of Alzheimer's Disease (AD). To initiate A¿ formation, ¿-secretase cleaves APP at the N-terminus of A¿ to release APPs¿ (~100 kDa soluble NT-fragment), and C99, a 12-kDa CT membrane fragment. Altern
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